An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

By S. Lehmann, C. Krüger, Boyoun Park, Katja Derkow, K. Rosenberger, Jan Baumgart, T. Trimbuch, G. Eom, Michael Hinz, D. Kaul and 15 more. Nature Neuroscience, 2012

736 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/54aec6f314d4b34be3c1016446178cde682d452d

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In Cancer Research

In Immunology

George A. Calin

Citations in the corpus

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “Extracellular miRNAs have also been reported to bind to Toll-like receptors (137), activate downstream signaling events, and eventually lead to biological responses, such as tumor growth and metastasis (138), and neurodegeneration (139).”
In vivo delivery of miRNAs for cancer therapy: Challenges and strategies (2014, background): “For example, miRNA let-7b can bind and activate TLR 7 signaling in neurons and induce neurodegeneration [79].”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “On immune cells, miRNAs can directly target Toll-like receptors (TLRs) by acting as their ligands, in turn activating TLR signalling pathways and inducing an immune response 40,42,43 .”