Intestinal barrier dysfunction in inflammatory bowel diseases.
By M. McGuckin, R. Eri, L. Simms, T. Florin, G. Radford-Smith. Inflammatory Bowel Diseases, 2009
641 citations recorded by the source corpus.
The etiology of human inflammatory bowel diseases (IBDs) is believed to involve inappropriate host responses to the complex commensal microbial flora in the gut, although an altered commensal flora is not completely excluded. A multifunctional cellular and secreted barrier separates the microbial flora from host tissues. Altered function of this barrier remains a major largely unexplored pathway to IBD. Although there is evidence of barrier dysfunction in IBD, it remains unclear whether this is a primary contributor to disease or a consequence of mucosal inflammation. Recent evidence from animal models demonstrating that genetic defects restricted to the epithelium can initiate intestinal inflammation in the presence of normal underlying immunity has refocused attention on epithelial dysfunction in IBD. We review the components of the secreted and cellular barrier, their regulation, including interactions with underlying innate and adaptive immunity, evidence from animal models of the barrier's role in preventing intestinal inflammation, and evidence of barrier dysfunction in both Crohn's disease and ulcerative colitis.
Subfields: Genetics, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/54813d26a5870652dfd08b79f3bc7f056535cb72
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Citations in the corpus
- Inflammatory responses and inflammation-associated diseases in organs (2015, background): “The complex, polygenetic inflammatory bowel diseases (IBDs) are characterized by an excessive inflammatory response to gut lumen microbial flora [151].”
- Microbiota in health and diseases (2022, background): “Specifically, the intestinal barrier would be susceptible to pathogen invasion without the secretion of antimicrobial peptides (AMPs) or tight junction proteins.(236) During initial disease in genetically susceptible individuals, the immune response is altered, leading to loss of immune tolerance to”
- Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria (2010, background): “The viscous matrix of mucus retains other secretions such as antimicrobial peptides, immunoglobulins, and shed cells (”