Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells.

By J. Gurr, A. S. Wang, Chien-hung Chen, K. Jan. Toxicology, 2005

1,022 citations recorded by the source corpus.

Subfields: Materials Chemistry, Renewable Energy, Sustainability and the Environment

View Paper: https://www.semanticscholar.org/paper/547590c404e6534aa883e1e56bfcfe4193c657a7

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In Materials Chemistry

1. Saber M. Hussain
2. John J. Schlager
3. R. Handy
4. J. Walker
5. Jacques Theron
6. T. E. Cloete
7. Christie M. Sayes
8. P. Biswas

In Renewable Energy, Sustainability and the Environment

1. J. Walker
2. Jacques Theron
3. P. Alvarez
4. T. E. Cloete

Citations in the corpus

• Crystal structure mediates mode of cell death in TiO2 nanotoxicity (2009, background): “Nantoxicity studies examining the effects of TiO2 have shown induction of inflammatory responses, cytotoxicity, and reactive oxygen species (ROS) formation in a variety of cell types and tissues (Renwick et al. 2004; Warheit et al. 2006; Grassian et al. 2007; Sayes et al. 2006; Gurr et al. 2005; Lon”
• NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, methodology): “There are several studies that clearly demonstrate that size does matter with respect to toxicological outcome, many of which have focused on carbon black, ZnO and TiO2 NPs versus microparticles.”
• Nanomaterials and nanoparticles: Sources and toxicity (2007, background): “Sun-illuminated titanium dioxide particles in sunscreen were observed to catalyze DNA damage both in vitro and in vivo [143], [278].”
• Genotoxic effects of zinc oxide and titanium dioxide nanoparticles on root meristem cells of Allium cepa by comet assay (2014, background): “Additionally, anatase (10 and 20 nm) TiO2 particles, in the absence of photo-activation, induce oxidative DNA damage, lipid peroxidation, micronuclei formation, and increased hydrogen peroxide and nitric oxide production in a human bronchial epithelial cell line (Gurr et al., 2005).”
• Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations (2014, neutral): “and micronuclei formation in the absence of light, whereas anatase nanoparticles of the same size and chemical composition did not [26].”
• Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety (2007, background): “The same mechanism may also explain the findings of a recent report on oxidative damage in human bronchial epithelial cells following exposure to rutile and anatase-type TiO2 (10, 20 and 200 nm) nanoparticles (Gurr et al., 2005).”
• Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. (2009, background): “However, it is not clear whether size-dependent structural changes contribute to an increase of toxicity in a general sense (see, for example, ref”
• Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations--many questions, some answers. (2009, methodology): “The most frequently used test was the Comet assay: 19 studies, 14 with positive outcome, the latter on the following materials (all in vitro except where stated): fullerenes [3], SWCNT [4], cobalt chrome alloy [5], TiO2 [6,8,14,15], V2O3 and V2O5 (K.”