Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi

By L. Cowen, Susan Lindquist. Science, 2005

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Life is Physics: Evolution as a Collective Phenomenon Far From Equilibrium (2010, background): “The physics of living systems would have at its core a generalized description of evolutionary processes, reflecting allowable dynamical symmetries, not merely static configurational ones.”
Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes (2012, background): “Cowen and colleagues (Cowen and Lindquist, 2005; Cowen et al., 2009) also demonstrated that HSP90 plays an important role in the drug resistance of yeast and fungus and could be a target for clinical therapy of yeast- and fungus-induced diseases.”
Arbuscular mycorrhiza and heavy metal tolerance. (2007, background): “HSP90, an abundant, evolutionarily conserved and highly stress-inducible molecular chaperone, regulates folding, transport, maturation and degradation of a variety of proteins (Cowen and Lindquist, 2005; Sangster and Queitsch, 2005).”
Adaptive laboratory evolution – principles and applications for biotechnology (2013, background): “Moreover, there is evidence that the interplay of protein mutational robustness, protein folding and environmental stress is an additional key factor that determines the evolution of new traits [145,146].”