Compartmentalized dendritic plasticity and input feature storage in neurons

By Attila Losonczy, Judit K. Makara, Jeffrey C. Magee. 2008

606 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Inhibitory synaptic plasticity: spike timing-dependence and putative network function (2013, background): “It was recently suggested that dendrites act as independent computational units (Poirazi et al., 2003; Losonczy et al., 2008; Branco and Häusser, 2010) that locally regulate many important cellular processes, such as plasticity and protein synthesis.”
The reorganization and reactivation of hippocampal maps predict spatial memory performance (2010, positive): “Indeed SWRs have been hypothesized to promote neuronal plasticity amongst active cells, and this process might be related to dendritic spiking 41 , 42 .”
Two opposing plasticity mechanisms pulling a single synapse. (2008, positive): “dendritic compartmentalization [35], culminating in the recent discovery that dendritic branches can function as individual units of plasticity [ 24 ].”
COORDINATION OF SIZE AND NUMBER OF EXCITATORY AND INHIBITORY SYNAPSES RESULTS IN A BALANCED STRUCTURAL PLASTICITY ALONG MATURE HIPPOCAMPAL CA1 DENDRITES DURING LTP (2011, background): “Physiological recordings and functional imaging supports this hypothesis (Gray et al., 2006; Losonczy and Magee, 2006; Tsuriel et al., 2006; Harvey and Svoboda, 2007; De Roo et al., 2008; Harvey et al., 2008; Losonczy et al., 2008; Rose et al., 2009; Zhong et al., 2009).”
Behavior-dependent short-term assembly dynamics in the medial prefrontal cortex (2008, background): “The ability of a given neuron to discharge its target may also depend on the activity of other presynaptic cell”
Why Neurons Have Thousands of Synapses, a Theory of Sequence Memory in Neocortex (2015, background): “This effect has been reported (Losonczy et al., 2008), though the phenomenon has yet to be widely established.”
Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes (2012, background): “Quartz prism sequence for reduction of cubic phase in a mode-locked Ti:Al(2)O(3) laser.”
Branching out: mechanisms of dendritic arborization (2010, background): “Second, the branching pattern and density of dendrites must be suitable for sampling and processing the signals that converge onto the dendritic fiel”
Frontiers in Synaptic Neuroscience Synaptic Neuroscience (positive): “The effect of neuromodulators on dendritic excitability is not restricted to short-term effects, since for example, the combination of mACh receptor activation with weak dendritic spikes in a distinct dendritic compartment resulted in a long-lasting excitability increase restricted to the involved d”
Reinforcement Learning on Slow Features of High-Dimensional Input Streams (2010, result): “We therefore propose a learning rule that is based on a more complex neuron model with nonlinear dendritic interactions within neurons [42] and the possibility to adapt dendritic conductance properties [43].”
Potassium channels control the interaction between active dendritic integration compartments in layer 5 cortical pyramidal neurons. (2013, positive): “Dendrites of pyramidal neurons, however, are not passive but are capable of generating regenerative electrical activity (Gasparini et al., 2004; Kim and Connors, 1993; Larkum and Zhu, 2002; Losonczy and Magee, 2006; Losonczy et al., 2008; Schiller et al., 1997, 2000; Williams and Stuart, 2002).”
Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop (2009, background): “…(Miles and Wong, 1986) and/or efficient temporal integration of spatially confined dendritic inputs from coherently active small group of cells (Losonczy et al., 2008) might explain how the fast firing minority can ‘‘drive’’ downstream neurons more effectively than the slow firing majority.”
Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons (2014, background): “How might heterosynaptic plasticity contribute to experience-dependent circuit remodeling? Several studies demonstrate that synaptic potentiation occurs in a spatially clustered manner both in vitro (De Roo et al., 2008; Losonczy et al., 2008) and in vivo (Fu et al.”
The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP (2011, methodology): “…then attempted to induce L-LTP by pseudosynchronous (<6 ms) stimulation of multiple spines within a single oblique tertiary apical dendritic branch (Losonczy and Magee, 2006; Losonczy et al., 2008) in ACSF containing 1 mM Mg+2, 2 mM Ca+2, and 100 mMof the D1R agonist SKF38393 (GLU+SKF stimulation).”