TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
By K. Ishii, T. Kawagoe, S. Koyama, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Satoshi Uematsu, O. Takeuchi, F. Takeshita, C. Coban and 1 more. Nature, 2008
676 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/5353dfd452f27e44afbe6e9eadf7d3b0b8c3f6e3
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In Immunology
- Shizuo Akira
- Zhijian J. Chen
- Taro Kawai
- O. Takeuchi
- Himanshu Kumar
- R. Medzhitov
- A. Bowie
- C. Reis e Sousa
Citations in the corpus
- Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “Finally, signaling through the non-canonical inhibitor of nuclear factor jB (IjB) kinase, TRAF family member-associated NF-jB activator (TANK)-binding kinase1, in radioresistant cells is critical for efficient CD8 T-cell responses in a DNA vaccination model (45).”
- RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (2009, neutral): “Although the DNA-binding protein DAI (ZBP1) has been proposed as a DNA sensor that induces type I IFNs, DAI-deficient mice and cells from these mice do not have apparent defects in producing type I IFNs in response to DNA stimulation (Ishii et al., 2008; Takaoka et al., 2007).”
- Viral evasion and subversion of pattern-recognition receptor signalling (2008, background): “DAI is one such cytoplasmic DNA receptor 4 , but its role in the in vivo recognition of cytoplasmic DNA has been controversial; additional cytoplasmic DNA receptors also probably have an important role 5, 74 .”
- STING Specifies IRF3 phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway (2012, background): “w DNA-dependent activator of IFN (DAI) has been suggested as a sensor of cytosolic DNA (13), DAI-deficient mice still produce IFNs in response to B-form DNA, and they have innate and adaptive immune responses that are similar to those of wild-type mice (14).”
- 5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I (2009, background): “Although the DNA-binding protein DAI (ZBP1) has been proposed as a DNA sensor that induces type I IFNs, DAI-deficient mice and cells from these mice do not have apparent defects in producing type I IFNs in response to DNA stimulation (Ishii et al., 2008; Takaoka et al., 2007).”