Mechanism of homologous recombination from the RecA–ssDNA/dsDNA structures

By Zhucheng Chen, Haijuan Yang, N. Pavletich. Nature, 2008

693 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/533fe8c4f898e5b24e018715c8315d3a1516e9c9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Jasin
2. M. Moynahan

In Molecular Biology

1. M. Moynahan
2. M. Jasin
3. Rodney Rothstein
4. J. Haber
5. Anuja S. Mehta
6. Stephen P. Jackson
7. Alan Ashworth
8. C. Lord

Citations in the corpus

• Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis (2010, positive): “The mechanism of strand exchange has recently been illuminated by crystal structure determinations of RecA filaments in complex with ssDNA and double-stranded DNA (dsDNA”
• Sources of DNA double-strand breaks and models of recombinational DNA repair. (2014, background): “This arrangement may facilitate pairing through canonical Watson–Crick hydrogen bonds with complementary triplets in the donor duplex DNA; when RecA or Rad51 binds to dsDNA, it also becomes stretched to 150% of its normal length (Chen et al. 2008).”
• Repair of strand breaks by homologous recombination. (2013, background): “The mechanism of strand exchange was illuminated by crystal structures of RecA filaments in complex with single- and double-stranded DNA (Chen et al. 2008), and is likely relevant to how Rad51 proteins function.”