Stem cells, self-renewal, and differentiation in the intestinal epithelium.

By Laurens G. van der Flier, Hans Clevers. Annual Review of Physiology, 2009

1,818 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/531df8013aedd0651fb9ea4aceef2effc4691efe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. C. Bevins
2. P. Bonaldo
3. F. Gattazzo
4. A. Urciuolo
5. Nita H. Salzman
6. K. Papadakis
7. Hans Clevers
8. G. Ramos

In Molecular Biology

1. Hans Clevers
2. C. Bevins
3. Nita H. Salzman
4. P. Bonaldo
5. I. Rønnestad
6. F. Gattazzo
7. A. Urciuolo
8. R. Nusse

In Oncology

1. P. Bonaldo
2. F. Gattazzo
3. A. Urciuolo
4. C. Bevins
5. Nita H. Salzman
6. Hans Clevers
7. Pengfei Lu

Citations in the corpus

• The intestinal crypt, a prototype stem cell compartment. (2013, methodology): “Six differentiated epithelial cell types are distinguished (Figure 2) (van der Flier and Clevers, 2009).”
• Mechanisms of Disease: Inflammatory Bowel Diseases. (2019, background): “Beyond just a promoting physical barrier between lumen and mucosa, IEC of the intestinal barrier consist of different cell types that maintain the equilibrium lumen-mucosa through different mechanisms, these include: enteroabsortive cells, goblet cells, neuroendocrine cells, Paneth cells and M cells”
• Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review. (2019, background): “For this reason, IECs are constantly shed and replaced by new enterocytes every 2–6 d, guided by an active proliferating layer at the base of the crypts of Lieberkühn guided by Wnt signaling (106, 107).”
• Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. (2010, neutral): “A fourth cell type, the Paneth cell, also derives from the stem cells but migrates downwards and settles at the crypt base to live for 6–8 weeks (van der Flier and Clevers, 2009).”
• Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “These cells can self-renew continuously and produce transit-amplifying daughter cells that differentiate in all cell types of the small intestinal epithelium, such as enterocytes, goblet cells, enteroendocrine cells and Paneth cells [160,161].”
• Feeding behaviour and digestive physiology in larval fish: current knowledge, and gaps and bottlenecks in research (2013, background): “…is lined by a monolayer of rapidly renewing cells, in which cellular proliferation and apoptosis are coordinated and regulated by cellsignalling events between the epithelial and mesenchymal layers (Theise 2005; Shi & Ishizuya-Oka 2001; RamalhoSantos et al. 2000; van der Flier & Clevers 2009).”