The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
By M. Welcker, A. Orian, Jianping Jin, Jonathan A. Grim, J. Harper, Robert N. Eisenman, B. Clurman. Proceedings of the National Academy of Sciences of the United States of America, 2004
963 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/530c1bb32baf1d798bd782a4634f42060b74466d
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Citations in the corpus
- Systematic analysis and nomenclature of mammalian F-box proteins. (2004, neutral): “c-MYC and cyclin E are targeted by ago/FBXW7 in both Drosophila and mammals (Koepp et al. 2001; Moberg et al. 2001, 2004; Strohmaier et al. 2001; Tetzlaff et al. 2004; Welcker et al. 2004), and Notch is targeted by sel-10/FBXW7 in both mammals and C.”
- c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I (2005, neutral): “In this regard, it is intriguing that the ubiquitin ligase isoform Fbw7γ, which also targets c-Myc for degradation and does not stimulate c-Myc transcriptional activit”
- Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma (2017, neutral): “3G34R/V it has been reported to play a role in MYC/ MYCN stabilization through its action as a component of the SCF-like ubiquitin ligase complex that targets MYC/MYCN for proteasomal degradation (Welcker et al., 2004; Yada et al., 2004).”
- Neuroblastoma and MYCN (2013, neutral): “4) (Sears et al. 2000; Welcker et al. 2004; Yada et al. 2004).”
- LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism (2005, positive): “A key step in the mechanism regulating Myc degradation involves its GSK3β-dependent phosphorylation on threonine 58 (T58) (Sears et al., 2000; Gregory et al., 2003; Welcker et al., 2004; Yeh et al., 2004).”