Design and gene delivery activity of modified polyethylenimines.

By R. Kircheis, L. Wightman, E. Wagner. Advanced Drug Delivery Reviews, 2001

633 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/52c7464c8ebf991cd65a99218ae2c4508100c802

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In Genetics

In Molecular Biology

Citations in the corpus

Knocking down barriers: advances in siRNA delivery (2009, background): “The intraperitoneal administration of complexed siRNA led to the delivery of the intact siRNA into the tumours and a marked reduction of tumour growth through siRNA-mediated downregulation of human epidermal growth factor 2 (HER2; also known as ERBB2) 91 .There has been significant concern regarding”
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging (2009, background): “For decades PEI-based polymers has been used for gene delivery thanks to their ability to complex with DNA, facilitate endosomal release via the “proton sponge effect”, and guide intracellular trafficking of their cargo into the nucleus [177,178].”
Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives (2005, background): “The poor stabilization against aggregation of these low molecular weight PEGPEI conjugates may be attributed to the formation of a structure differing from that of the core-corona model [70].”
In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. (2003, background): “The free polymer then interacts with cell membranes, extracellular matrix proteins and blood components leading to undesired side effects [7].”
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues (2008, background): “The dual capacity to form polyvalent adhesive interactions via both hydrophobic and anionic forces represents a particularly challenging problem for polymeric nanoparticles designed to deliver drugs and genes, since many commonly used biomaterials are either hydrophobic, such as poly(lactideco-glyco”