In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis.

By D. Fischer, Youxin Li, B. Ahlemeyer, J. Krieglstein, T. Kissel. Biomaterials, 2003

2,105 citations recorded by the source corpus.

Subfields: Molecular Biology, Polymers and Plastics

View Paper: https://www.semanticscholar.org/paper/9287c91709cd5912facef4a1d481a3a2540ab8ee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. L. Ensign
2. J. Hanes
3. T. Kissel
4. I. Uchegbu
5. C. Dufès
6. A. Schätzlein
7. Namho Kim
8. J. S. Suk

In Polymers and Plastics

1. Keerti Jain
2. T. Kissel
3. I. Uchegbu
4. C. Dufès
5. A. Schätzlein
6. N. Jain

Citations in the corpus

• PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, positive): “For example, cationic polymers widely utilized to formulate synthetic DNA NPs, including polyethylenimine (PEI), poly-L-lysine and poly (amido amine) (PAMAM) dendrimers, were shown to interact with and damage the membranes of erythrocytes [74, 75].”
• Dendrimer toxicity: Let's meet the challenge. (2010, background): “Not only dendrimers but also cationicmacromolecules in general cause destabilization of the cell membrane and result in cell lysis (Rittner et al., 2002;Honget al., 2006a; Fischer et al., 2003).”
• Magnetic Nanoparticles: Surface Effects and Properties Related to Biomedicine Applications (2013, background): “requires controlling particle material, size and coating properties [90,102–104].”
• Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION) (2010, background): “The transient cell growth and proliferation observed in the study may be due to additional nutrients present within the cells in the form of iron and phospholipids for the viable cells stimulating cell growth (79).”
• Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives (2005, background): “Recent Fourier transform infrared (FTIR) data has shown a reduction in the frequency of the asymmetric phosphate stretching vibration of plasmid DNA after complexation with PEI, which may be attributed to electrostatic interactions between DNA and the polymer [17].”
• Dendrimers in gene delivery. (2005, background): “6 kDa), or DEAE–dextran (500 kDa) which in these assays are around 3 orders of magnitude more toxic [58].”