Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction

By F. Castellino, A. Huang, G. Altan-Bonnet, S. Stoll, C. Scheinecker, Ronald N. Germain. Nature, 2006

868 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/52ac4d74ae8617d79e5781aa7d274c5ee63f0479

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In Immunology

Citations in the corpus

International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “Engagement of naive CD4+ T cells with antigen presenting cells (APCs) triggers secretion of CCL3 and CCL4, which favors CCR5-dependent guidance of naive CD8+ T cells toward DC-CD4+ T-cell conjugates and promotes memory CD8+ T-cell survival and function (Castellino et al., 2006).”
Quantitative challenges in understanding ligand discrimination by αβ T cells (2008, background): “T cells must be able o be efficiently activated by infected or professional antigen preenting cells (APCs) bearing foreign ligands, while remaining or the most part in a naı̈ve state upon interaction with normal uninfected) cells.”
Orchestrating the orchestrators: chemokines in control of T cell traffic (2008, background): “However, given the rapid antigen-independent induction of CCR5 on naive CD8 + T cells at inflamed site”
Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment (2009, background): “Recent work has suggested that CXCR4 and CCR5 may cooperatively provide a costimulatory signal for T-cell activation (16) and that CCR5 on CD8 T cells may be important for the generation of a memory phenotype (17).”
Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “One possible mechanism for early CD4+ T cell help for CD8+ T cells is by the enhancement of naive CD8+ T cell chemotaxis to helped DCs (Castellino et al., 2006).”
The chemokine system in innate immunity. (2015, background): “In response to CD4þ T-cell and DC interactions, both cells secrete CCR5 ligands, which bind to a subset of CD8þ T cells within the LN (Castellino et al. 2006).”
Expanding roles for CD4+ T cells in immunity to viruses (2012, background): “For example, chemokines produced following antigen-specific interactions between APCs and CD4 + T cells can actively attract CD8 + T cells to the activated APC”
The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection (2009, background): “…for B and T lymphocytes in lymph nodes as they seek out cognate antigen on other lymphocytes, a process also governed by chemotactic signals (Castellino et al., 2006; Okada et al., 2005)—a comparison made yet more intriguing by reports that the mature tuberculous granuloma has structural…”
CD8+ T Cells: Foot Soldiers of the Immune System (2011, positive): “In addition, chemokines such as CCL3, CCL4, and CCL17 produced by DCs have been shown to attract cognate CCR5 + or CCR4 + naive CD8 + T cells during priming (Castellino et al., 2006; Semmling et al., 2010).”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “These chemokines bind to CCR5 on naive CD8+ T cells, promoting their migration to CD4+ T cell/DC clusters (139).”