Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake

By Jian V. Zhang, Pei-Gen Ren, Orna Avsian-Kretchmer, C. Luo, Rami Rauch, C. Klein, A. Hsueh. Science, 2005

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Neuroendocrine control of food intake. (2008, background): “Administered to rats, this peptide has been found to bind the orphan receptor known as GPR39, to suppress food intake and decrease body weight [40].”
The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review (2007, background): “, it was demonstrated that desacyl ghrelin and obestatin (which are peptides derived from the same ghrelin gene, that undergo differential post-translational modifications) also play a role in energy balance (120,152).”
Gut hormones and the regulation of energy homeostasis (2006, background): “Peptide YY and the Y2 agonist PYY-(13-36) inhibit neurons of the dorsal motor nucleus of the vagus.”
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. (2008, critical): “’’ A recent claim that obestatin binds to a G protein coupled receptor and acts as a ghrelin antagonist (Zhang et al., 2005) has been refuted (Chartrel et al.”
The Hormonal Control of Food Intake (2007, positive): “has suggested that subtle but distinctly different processing of this precursor generates a peptide that directly opposes the effect of ghrelin on food intake (Zhang et al., 2005).”