Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover.

By M. Manefield, T. B. Rasmussen, Morten Henzter, J. B. Andersen, Peter D. Steinberg, S. Kjelleberg, M. Givskov. Microbiology, 2002

605 citations recorded by the source corpus.

Subfields: Endocrinology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/52680aacc21dcd4d374d4751a879376e1adbf4e1

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Citations in the corpus

Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector (2005, background): “The furanones prevent the AHLs from binding to the luxR homologues and eventually cause a rapid turnover of these proteins (29, 31).”
Climate change and disease: bleaching of a chemically defended seaweed (2011, background): “Halogenated furanones produced by D. pulchra function (in part) by acting as chemical antagonists to bacterial cell–cell signalling systems or ‘quorum sensing’ (Manefield et al., 1999, 2002).”
Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance (2020, background): “Thus, they function as antagonist of LuxR and repress expression of QS-induced genes [211,212].”
Quorum sensing: cell-to-cell communication in bacteria. (2005, background): “The furanones are internalized by bacteria, bind to LuxR-type proteins, and cause the degradation of these proteins (Manefield et al. 2002).”
Inter-kingdom signalling: communication between bacteria and their hosts (2008, background): “The exact mechanism of action is unknown, but it is thought to increase the turnover of bacterial AHL-induced transcription factor”
SPORE RELEASE IN ACROCHAETIUM SP. (RHODOPHYTA) IS BACTERIALLY CONTROLLED 1 (2007, methodology): “These are structural homologs of AHL, bind in a competitive manner to the AHL-receptor-protein complex LuxR (Manefield et al. 1999), and consequently cause its destabilization and denaturation (Manefield et al. 2002).”
CHEMICAL MEDIATION OF COLONIZATION OF SEAWEED SURFACES1 (2002, background): “The compounds act at the LuxR homologous receptor proteins in these systems, interfering with binding of the bacterial AHLs, and ultimately leading to a degradation of the receptor protein (Manefield et al. 2002).”
Targeting virulence: a new paradigm for antimicrobial therapy (2007, background): “and seem to function by accele-rating the turnover of LuxR homolog”
The role of root exudates in rhizosphere interactions with plants and other organisms. (2006, background): “coli cells engineered to overproduce LuxR receptors (116), leading to reduced LuxR activity by destabilizing this protein, and resulting in accelerated proteolytic degradation (115).”
The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa (2012, background): “Although their exact mode of action remains uncharacterized, it has been suggested that the effects of furanones are related to a reduction in LuxR concentration (125).”