Neurofibromas in NF1: Schwann Cell Origin and Role of Tumor Environment

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Normal stem cells and cancer stem cells: the niche matters. (2006, background): “supported by the fact that certain types of neuroblastoma require coordination of mutations in both Schwann cells and supportive cells (71) and, in general, rapid tumor growth requires de novo angiogenesis, in which the vascular niche provides growth-”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Nf1-deficient Schwann cells are less tumorigenic in wild-type environments, apparently because wild-type fibroblasts and mast cells are not recruited as efficiently or are less able to secrete factors that promote tumor growth (Zhu et al., 2002).”
An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1 (2010, background): “Inherited NF1 mutations are associated with a variety of tumors, including neurofibromas, which reportedly have a Schwann cell–like origin (Zhu et al., 2002).”