Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation

By Bo Xu, Seong-tae Kim, M. Kastan. Molecular and Cellular Biology, 2001

609 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5210b29f29aa3a0aea4dd9db364fa8146cd0ff8c

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In Cancer Research

1. J. Bartek
2. J. Lukas
3. C. Lukas
4. P. Johnston
5. Yosef Shiloh
6. Alan Ashworth
7. R. Abraham
8. D. Longley

In Molecular Biology

1. J. Bartek
2. J. Lukas
3. C. Lukas
4. Yosef Shiloh
5. R. Abraham
6. K. Gudmundsdottir
7. P. Johnston
8. Alan Ashworth

Citations in the corpus

• Toward maintaining the genome: DNA damage and replication checkpoints. (2002, background): “Mutations in the checkpoint protein BRCA1, another substrate of ATM, result in defects in S-phase and G2 arrest (220) and also cause defects in DNA repair (1, 15, 135).”
• Checking on DNA damage in S phase (2004, background): “Consistent with their involvement in the intra-S-phase checkpoint, inactivating mutations and/or small interfering RNA (siRNA)-mediated depletion of any of these mediators gives rise to RD”
• The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (2006, background): “After damage by IR the activation of the intra-S phase checkpoint requires phosphorylation of BRCA1 on Ser1387 by ATM, and, additionally, BRCA1 has been reported to stimulate the transcription of p27, which induces intraS phase arrest (Williamson et al., 2002; Xu et al., 2002).”
• Molecular mechanisms of drug resistance (2005, background): “BRCA1 also plays a role in the activation of cell cycle checkpoints in response to different types of cellular stress including DNA damage and disruption of microtubule dynamics [150–152].”
• ATM and related protein kinases: safeguarding genome integrity (2003, background): “, its phosphorylation by ATM on Ser1423 spurs its involvement in the G2–M checkpoin”
• Cell cycle checkpoint signaling through the ATM and ATR kinases. (2001, background): “Like the NBS1 complex, BRCA1 participates in both checkpoint and repair pathways in DNA-damaged cells (Scully and Livingston 2000; Scully et al. 2000; Xu et al. 2001).”
• BRCA1 and BRCA2: different roles in a common pathway of genome protection (2011, background): “The exact mechanism of BRCA1–BARD1 control of the S-phase and G2/M checkpoints is not well characterize”