T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

By Hiroshi Takayanagi, K. Ogasawara, S. Hida, T. Chiba, S. Murata, Kojiro Sato, A. Takaoka, T. Yokochi, H. Oda, Keiji Tanaka and 2 more. Nature, 2000

1,093 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/51d76fe0420b6c51e4590d83b731c99e72d85087

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Teitelbaum
2. Hiroshi Takayanagi
3. Tadatsugu Taniguchi
4. E. Wagner

In Immunology

1. Hiroshi Takayanagi
2. L. Ivashkiv
3. Tadatsugu Taniguchi
4. Xiaoyu Hu
5. T. Takai
6. Shizuo Akira

In Molecular Biology

1. Hiroshi Takayanagi
2. S. Teitelbaum
3. G. Karsenty
4. F. Ross
5. E. Wagner
6. D. Lacey
7. W. J. Boyle
8. S. Murata

Citations in the corpus

• Reaching a genetic and molecular understanding of skeletal development. (2002, background): “Geneti-of osteoclast differentiation (Takayanagi et al., 2000; see cally, c-Fos can be placed downstream of PU.1 in thealso below). pathway leading to osteoclast differentiation (Figure 5).”
• Immunoproteasome assembly and antigen presentation in mice lacking both PA28α and PA28β (2001, background): “Recently, Takayanagi et al. (2000) demonstrated that osteoclastogenesis induced by RANKL [receptor activator of nuclear factor (NF)-kB ligand] was inhibited when co-stimulated with IFN-g, and that this inhibition was caused by accelerated ubiquitin± proteasome-dependent proteolysis of TRAF6, an…”
• Osteoclast differentiation and activation (2003, background): “Binding of INF-γ to its receptor leads to degradation of TRAF6, and can have an inhibitory effect on osteoclastogenesis in vitro”
• Genetic regulation of osteoclast development and function (2003, background): “For example, LPS-induced osteoclastogenesis and bone resorption are blunted in IFNα-receptor-deleted mic”
• RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β (2002, background): “Briefly, binding of RANKL to its receptor, RANK, results in the recruitment of TRAF family proteins such as TRAF6 (TNF receptor-associated factor 6), which activates the NF-κB and JNK pathways”
• Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis (2004, methodology): “To investigate the molecular basis of this discrepancy, we stimulated BMMs with RANKL and M-CSF after strictly depleting the stromal/osteoblastic cell”