Molecular basis for chemoprevention by sulforaphane: a comprehensive review

By N. Juge, R. Mithen, M. Traka. Cellular and Molecular Life Sciences, 2007

712 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/51d74da61822f49ae385050d3e0718349cd4ee54

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Bharat B. Aggarwal
2. K. Harikumar
3. J. Kundu
4. Bokyung Sung
5. H. Na
6. P. Anand
7. C. Sundaram
8. Y. Surh

In Organic Chemistry

1. J. Kundu
2. H. Na
3. Y. Surh

Citations in the corpus

• Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals (2008, positive): “Sulforaphane induces Nrf2-driven phase 2 enzyme expression by modulating the activation of MAP kinases [54], [63], [64], [65], [66], [67].”
• Cancer is a Preventable Disease that Requires Major Lifestyle Changes (2008, background): “The mechanisms of action of SFN include inhibition of phase 1 enzymes, induction of phase 2 enzymes to detoxify carcinogens, cell-cycle arrest, induction of apoptosis, inhibition of histone deacetylase, modulation of the MAPK pathway, inhibition of NF-κB, and production of ROS.”
• Physiological effects of broccoli consumption (2008, background): “These data suggest that whole broccoli can affect tumorigenesis, not just initiation, and these findings are supported by numerous cell culture studies aimed at identifying mechanism of SF- and DIM-induced cell cycle arrest and apoptosis of transformed cells (reviewed in Aggarwal and Ichikawa 2005; ”