The “cancer immunogram”

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Generation of tumor-reactive T cells by co-culture of peripheral blood lymphocytes and tumor organoids (2018, background): “Treatment failure may be explained at many different levels that include a low number of immunogenic antigens, defective antigen presentation, and/or the expression of alternative immune checkpoint molecules (Blank et al., 2016; Dijkstra et al., 2016; Pitt et al., 2016; Sharma et al., 2017).”
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy. (2018, background): “…including ‘‘foreignness’’ (includingmutational load) (Snyder et al., 2014), aspects of tumor metabolism (such as glucose metabolism), and factors affecting tumor sensitivity to immune effectors (including human leukocyte antigen [HLA] and interferon gamma gene expression) (Blank et al., 2016).”
Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment (2017, background): “Our findings may aid in the implementation of immunotherapy approaches (Blank et al., 2016) in a disease type with very limited treatment options.”
T Cell Dysfunction in Cancer (2018, background): “The mechanisms underlying this lack of responsiveness are highly multifactorial (Blank et al., 2016).”