Interactions Between Human Mesenchymal Stem Cells and Natural Killer Cells

By P. Sotiropoulou, S. Perez, A. Gritzapis, C. Baxevanis, M. Papamichail. Stem Cells, 2006

957 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/510f60ebe266543a7ed8978c08a25310c10b83cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. A. Caplan
2. P. Robey
3. L. Meirelles
4. D. Prockop
5. J. Karp

In Immunology

1. Vito Pistoia
2. L. Moretta
3. Antonio Uccelli

In Molecular Biology

1. A. Caplan
2. P. Robey

Citations in the corpus

• Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing (2010, background): “cells can modulate NK cell function most effectively [ 56 ] .”
• Immunobiology of mesenchymal stem cells (2013, result): “Besides DCs and macrophages, NK cells can also be suppressed by MSCs through soluble factors, such as TGF-b and prostaglandin E2 (PGE2).(41) Similar results are observed with human cells that MSCs inhibit IL-2- or IL-15-driven NK cell proliferation.”
• Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, neutral): “MSCs may also exert their therapeutic activity through direct cell-to-cell contact with the cells of the immune system [85,86] and/or the tissue to be repaired [51].”
• Bone marrow stromal cells attenuate sepsis via prostaglandin E2—dependent reprogramming of host macrophages to increase their interleukin-10 production (2008, positive): “BMSCs have been shown to produce prostaglandin E 2 and possibly affect other immune cells via EP1–EP4 receptor”
• Mesenchymal stem cells in health and disease (2008, result): “Similar to resting NK cells, pre-activated NK cells had decreased proliferation, IFNγ production and cytotoxicity after culture with MSCs in vitro”
• Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “Also, adipose tissue-derived MSCs have been shown to express HGF, VEGF, transforming growth factor beta (TGF-b), basic fibroblast growth factor (bFGF, aka FGF2) and granulocyte–macrophage colony-stimulating factor (GM-CSF), and the expression of these molecules was found to increase under hypoxic cu”
• Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis (2010, background): “Mesenchymal stem cells have been shown to possess immunomodulating properties, inducing suppression of various immune cell populations.(7-14) Mesenchymal stem cells cultivated under different culture manipulations (chemical induction or use of growth factors) can give rise to neural-like, glial-like”
• Humanized mice in translational biomedical research (2007, background): “In addition, because human HSCs, embryonic stem cells and mesenchymal stem cells are all sensitive to NK-cell-mediated killin”