A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).

By Subhra K. Biswas, Lisa M Gangi, Saki Paul, T. Schioppa, Alessandra Saccani, M. Sironi, B. Bottazzi, A. Doni, Bronte Vincenzo, F. Pasqualini and 4 more. Blood, 2006

761 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/51072e2c7e728ca741887070ab4e5cc62a103a9d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. J. Pollard
4. P. Allavena
5. F. Balkwill
6. F. Martínez
7. C. Garlanda
8. D. Hanahan

In Oncology

1. A. Mantovani
2. J. Pollard
3. A. Sica
4. P. Allavena
5. F. Balkwill
6. F. Martínez
7. C. Garlanda
8. R. Weinberg

Citations in the corpus

• The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “Macrophages in tumours — usually termed tumour-associated macrophages (TAM) — often express many genes typical of the M2 phenotyp”
• Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “Thus, the unmatched adaptability of macrophages in response to environmental signals goes beyond the original M1/M2 dichotomy, as is already evident in the early profiling of tumorassociated macrophages (TAMs) (34).”
• M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide (2015, background): “In malignant tumors, macrophages exhibit predominantly an M2-like phenotype [3, 31, 32].”
• Cancer-related inflammation (2008, background): “, tumour-associated macrophages (TAMs) have delayed and defective NF-κB activatio”
• A CREB-C/EBPβ cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair (2009, background): “Tumorassociated macrophages with an M2 phenotype activate signaling through IRF3/STAT1 and suppress NF- B activation (5).”
• Macrophage activation and polarization. (2008, background): “In agreement with the M2 signature, TAM also express high levels of both the scavenger receptor A (73) and the mannose receptor (Allavena P, and Sica A; unpublished observation).”
• Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages (2015, methodology): “Resting TAM are characterized by high expression of CCL2, CCL5, and IL-10 and surface molecular markers such as MGL1, Dectin-1, CD81, MHC-II, and scavenger receptor A (121, 124).”
• Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB (2009, methodology): “For phospho-STAT1 analysis, protein extracts were processed as described previously (40).”