Peroxisome proliferator-activated receptor α target genes

By S. Mandard, Michael Müller, S. Kersten. Cellular and Molecular Life Sciences (CMLS), 2004

877 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/50641288e60ce1b40b865140c9051463a1640628

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In Cardiology and Cardiovascular Medicine

In Molecular Biology

Citations in the corpus

Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture (2008, background): “A number of studies (reviewed in Mandard et al., 2004) have demonstrated that PPARα regulates genes involved in fatty acid oxidation, amino acid metabolism, and glucose homeostasis.”
The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide (2005, background): “If PEA activates PPAR- , this compound should also modulate the expression of PPAR- –regulated genes (Berger and Moller, 2002; Mandard et al., 2004).”
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006, background): “PPAR (cid:1) is expressed at high levels in organs that carry out significant catabolism of fatty acids such as the brown adipose tissue, liver, heart, kidney, and intestine (Mandard et al., 2004).”
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, neutral): “…is primarily involved in regulation of genes involved in fatty acid oxidation, ketogenesis, gluconeogenesis, cholesterol catabolism and lipoprotein metabolism (Lefebvre et al. 2006; Mandard et al. 2004), as well as anti-inflammatory genes (Michalik and Wahli 2008; Zandbergen and Plutzky 2007).”
Nutritional management of the transition cow in the 21st century – a paradigm shift in thinking (2013, background): “The pathways that can be affected by nuclear receptors encompass not only FA oxidation and ketogenesis but also gluconeogenesis andureagenesis (Mandard et al. 2004).”
A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation (2010, background): “Activation of PPARα and PPARβ by (dietary) fatty acids such as oleic acid makes tissues more dependent on FAO, by stimulating cellular fatty acid utilisation pathways including transport, esterification, and oxidation (Mandard et al. 2004).”
Integrated physiology and systems biology of PPARα (2014, background): “Detailed map of PPARa-mediated gene regulation Gene expression analysis of livers of PPARa / mice at the level of individual genes or the entire genome via transcriptomics has indicated that PPARa governs many aspects of hepatic lipid metabolism, providing a molecular basis for the pronounced metabo”