Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.

By N. Khan, F. Afaq, M. Saleem, N. Ahmad, H. Mukhtar. Cancer Research, 2006

810 citations recorded by the source corpus.

Subfields: Applied Microbiology and Biotechnology, Biochemistry, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/505dff5278a7d74e684ba21b50cd169782da57d3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Applied Microbiology and Biotechnology

1. H. Mukhtar
2. N. Khan

In Biochemistry

1. N. Khan
2. H. Mukhtar
3. J. Lambert
4. R. Elias

In Pathology and Forensic Medicine

1. N. Khan
2. H. Mukhtar
3. H. Rupasinghe
4. R. Elias

Citations in the corpus

• Tea polyphenols for health promotion. (2007, background): “Molecular mechanisms, including catechin-mediated induction of apoptosis and cell cycle arrest, inhibition of transcription factors NF-κB and AP-1 and reduction of protein tyrosine kinase activity and c-jun mRNA expression have also been suggested as relevant chemopreventive pathways for tea (Mukhta”
• Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives. (2006, background): “For these reasons, the authors have selected not to discuss many aspects of EGCG research that have been summarized elsewhere (Doss et al., 2005, Adhami et al., 2003, Haslam, 1996, Khan et al., 2006, Conney, 2003).”
• Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action (2010, background): “Polyphenols may exert these anticancer effects via a variety of mechanisms, including removal of carcinogenic agents [37,49], modulation of cancer cell signaling [48,55] and cell cycle progression [15,16], promotion of apoptosis [12-14] and modulation of enzymatic activities [56].”
• The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention (2010, background): “These mechanisms include the inhibition of growth factor signaling, inhibition of key cellular enzymes, inhibition of gene transcription, and induction of tumor suppressor genes (reviewed in [7–10]).”
• Kinase-targeted cancer therapies: progress, challenges and future directions (2018, background): “Well explored bioactive molecules such as resveratrol [228], curcumin [256], quercetin [235] and green tea polyphenols [257] inhibit PI3K pathway.”
• Tea Polyphenols in Promotion of Human Health (2018, positive): “We have earlier discussed the anticarcinogenic effects of green tea, its effects on various receptor tyrosine kinases, signal transduction pathways and metastasis [1,5,6].”