Platelet-collagen interaction: is GPVI the central receptor?

By B. Nieswandt, S. Watson. Blood, 2003

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Platelet-neutrophil-interactions: linking hemostasis and inflammation. (2007, background): “immunoglobulin-like domain, a mucin stalk, a transmembrane domain, and a short cytoplasmatic chain.(25) The transmembrane domain possesses an arginine group that links GPVI to FcR c-chain through a salt bridge.”
Kindlin-3 is essential for integrin activation and platelet aggregation (2008, background): “The shift is mediated through binding of the cytoskeletal protein Talin to the β subunit cytoplasmic tai”
Defective thrombus formation in mice lacking coagulation factor XII (2005, background): “Other candidates include substances liberated from disintegrating cells or exposed in the extracellular matrix (ECM) such as HSP90 (44) or soluble and insoluble polyanions, such as nucleosomes or glycosaminoglycans (45).”
DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. (2020, background): “Platelets are activated by coagulation factors, such as vonWillebrand factor [through the glycoprotein (GP)-Ib receptor], fibrinogen and fibronectin (through the GPIIb–GPIIIa receptor), as well as by contact with other extracellular matrix (ECM) proteins, such as collagen (through the GPVI receptor)”
New fundamentals in hemostasis. (2013, background): “For the presence of collagen receptors other than GPVI and 2 1 on platelets is only limited evidence (203).”