Engineering hydrogels as extracellular matrix mimics
By Hikmet Geçkil, Feng Xu, Xiaohui Zhang, Sangjun Moon, Utkan Demirci. Nanomedicine, 2010
880 citations recorded by the source corpus.
Extracellular matrix (ECM) is a complex cellular environment consisting of proteins, proteoglycans, and other soluble molecules. ECM provides structural support to mammalian cells and a regulatory milieu with a variety of important cell functions, including assembling cells into various tissues and organs, regulating growth and cell–cell communication. Developing a tailored in vitro cell culture environment that mimics the intricate and organized nanoscale meshwork of native ECM is desirable. Recent studies have shown the potential of hydrogels to mimic native ECM. Such an engineered native-like ECM is more likely to provide cells with rational cues for diagnostic and therapeutic studies. The research for novel biomaterials has led to an extension of the scope and techniques used to fabricate biomimetic hydrogel scaffolds for tissue engineering and regenerative medicine applications. In this article, we detail the progress of the current state-of-the-art engineering methods to create cell-encapsulating hydrogel tissue constructs as well as their applications in in vitro models in biomedicine.
Subfields: Biomaterials, Biomedical Engineering, Surgery
View Paper: https://www.semanticscholar.org/paper/8d7642900e2849b0922cd2eeb3399785c889c617
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Citations in the corpus
- Design properties of hydrogel tissue-engineering scaffolds (2011, background): “It is highly desirable to ensure that the biodegradation rate coincides with new tissue regeneration at the defect site [2,6,8].”
- Hydrogel scaffolds for tissue engineering: Progress and challenges (2013, background): “In spite of the relatively successful clinical translation of several engineered tissues, such as lung tracheal segments(194) and tissue engineered bladders,(195) various significant challenges are still associated with the use of hydrogel scaffolds and also with the applied scaffolding techniques i”
- A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds (2021, background): “Polymerization, interlinkage, and functionality (changed by block structures, by combining them, by copolymerization) of their molecular weight, molecular structure, physical and chemical features make them easily synthesized as compared to naturally occurring polymers [83,84].”