Bap, a Staphylococcus aureus Surface Protein Involved in Biofilm Formation

By C. Cucarella, C. Solano, Jaione Valle, B. Amorena, Í. Lasa, J. Penadés. Journal of Bacteriology, 2001

935 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/501e3f02bb02bcdfac019199459ce28a3b6436d6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Otto
2. K. Schleifer
3. A. Horswill
4. P. Watnick
5. Jessica L. Lister
6. J. Ghigo
7. E. Karatan
8. Robert C. Edgar

In Infectious Diseases

1. Jessica L. Lister
2. M. Otto
3. A. Horswill
4. Aleeza J. Roth
5. Matthew J. Thoendel
6. P. Watnick
7. E. Karatan
8. Blaise R. Boles

In Molecular Biology

1. M. Otto
2. Jessica L. Lister
3. A. Horswill
4. P. Watnick
5. E. Karatan
6. Matthew J. Thoendel
7. Aleeza J. Roth
8. Blaise R. Boles

Citations in the corpus

• ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus. (2007, background): “The first well-characterized icaADBC-independent biofilm mechanism was described by the research groups of J. Penades and I. Lasa, who demonstrated that the biofilmassociated protein (Bap) was essential for both initial adherence and intercellular accumulation during biofilm development by the S. au”
• Staphylococcal biofilms (2018, background): “These proteins contain many surface binding proteins of the MSCRAMM family in addition to the bio fi lm-associat-ed protein (Bap), found in S. aureus mastitis isolates, of which a homologue (Bhp) is present in S. epidermidis (63, 64).”
• The pgaABCD Locus of Escherichia coli Promotes the Synthesis of a Polysaccharide Adhesin Required for Biofilm Formation (2004, background): “Macromolecules that have been reported to stabilize biofilm structure include cellulose, nucleic acids, and proteins (12, 48, 58, 59, 66).”
• Insights on Evolution of Virulence and Resistance from the Complete Genome Analysis of an Early Methicillin-Resistant Staphylococcus aureus Strain and a Biofilm-Producing Methicillin-Resistant Staphylococcus epidermidis Strain (2005, background): “aureus isolates, where it has key roles in adherence to polystyrene surfaces, intercellular adhesion, and biofilm formation (12, 13, 49), but has not been found in human clinical S.”
• The Enterococcal Surface Protein, Esp, Is Involved in Enterococcus faecalis Biofilm Formation (2001, background): “We searched eubacterial genome databases for sequence homologies to the S. aureus Bap protein using the gapped BLASTP program (1) and found that Bap and Esp share 33% sequence identity and 50% sequence similarity in an overall alignment.”
• Coagulase-Negative Staphylococci (2014, background): “aureus isolates associated with bovine mastitis produce a 240-kDa surface protein, called biofilm-associated protein (Bap), which mediates attachment to polystyrene and the accumulation phase of biofilm production (see below) (252).”
• Identification of Genes Involved in Polysaccharide-Independent Staphylococcus aureus Biofilm Formation (2010, background): “Protein-mediated biofilm formation has emerged as a prominent alternative to PIA, and many surface adhesins, such as Bap [11], Spa [12], FnBPA and FnBPB [13], and SasG [14,15], have been implicated in this divergent biofilm mechanism.”
• Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, background): “Furthermore, staphylococcal isolates from human clinical samples harboring this gene form thicker biofilms (60).”
• Bacterial cell attachment, the beginning of a biofilm (2007, background): “[22] identified two mutants of Staphylococcus aureus with the use of the transposon Tn917, with a significant decrease in attachment to inert surfaces.”
• Genetic analysis of Salmonella enteritidis biofilm formation: critical role of cellulose (2002, background): “, 1997), Staphylococcus aureus (Cucarella et al., 2001) and Streptococcus gordonii (Loo et al.”
• Staphylococcus and biofilms (2002, background): “aureus transposon–insertion mutant has been isolated with a significant decrease in attachment to inert surfaces, intercellular adhesion and biofilm formation (Cucarella et al., 2001).”
• The Genera Staphylococcus and Macrococcus (2006, background): “Other proteins can also contribute to biofilm formation in staphylococci, such as the accumulation-associated protein (AAP; Hussain et al., 1997) and the biofilm-associated protein (Bap; Cucarella et al., 2001) .”
• agr-Mediated Dispersal of Staphylococcus aureus Biofilms (2008, background): “One potential target is the surface adhesins, and possible candidates include the surface proteins Atl, Bap, and SasG, all of which have reported roles in biofilm formation [41,42,71–73].”
• Bacterial Biofilm and its Role in the Pathogenesis of Disease (2020, background): “The bap gene has been identified in up to 25% S. aureus isolates and up to 95% of CNS isolates from bovine mastitis [144, 145] , and up-regulation of the bap gene with the presence of low concentrations of milk or lactose in the growth medium has been shown in vitro [141, 146] .”