Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases.

By Sandrine Boissier, M. Ferreras, O. Peyruchaud, S. Magnetto, F. Ebetino, M. Colombel, P. Delmas, J. Delaissé, P. Clézardin. Cancer Research, 2000

614 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4fe016607f95c43a6b49e673ff255e187ea5c4ed

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1. E. Giraudo
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Citations in the corpus

• Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. (2002, background): “We have reported previously a similar structure-activity relationship of BPs on inhibition of cancer cell invasion and adhesion to bone (5, 6).”
• An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. (2004, background): “By contrast, a related protease, MMP-2, was constitutively expressed in all stages (Figure 2A); mRNAs for seven other MMPs were analyzed, and we observed unchanged or undetectable levels of expression (see Supplemental Figure 1, available at http://www. jci.org/cgi/content/full/114/5/623/DC1).”