Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats.

By Pierrick G. J. Fournier, Sandrine Boissier, S. Filleur, J. Guglielmi, F. Cabon, M. Colombel, P. Clézardin. Cancer Research, 2002

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An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. (2004, methodology): “every day with ZA (100 μg/kg) delivered by subcutaneous injection (26, 27).”
Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research (2010, background): “Still, primary studies in nonskeletal tissues suggest that angiogenesis indeed may be reduced by BPs over and above the normal reduction that would occur because of the absence of effective osteoclastic tunneling.((70)) Interestingly, in a rat model of stress fracture, there is upregulation of vascu”