Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding
By F. Nimmerjahn, J. Ravetch. Science, 2005
1,089 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/4fc685b32164678325d591b558d056d2420da26f
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In Immunology
- F. Nimmerjahn
- J. Ravetch
- A. Korman
- R. Flavell
- I. Waldhauer
- Shizuo Akira
- R. Medzhitov
- Alexander Y. Rudensky
In Molecular Biology
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose (2011, background): “Removal of core fucose selectively and significantly increases binding affinity to FcγRIII and leads to enhanced cellular immune effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) both in vitro (9) and in vivo (10).”
- Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells (2013, background): “Murine IgG2b can bind to immunoglobulin Fcg receptors (FcgR), including FcgRIIB, FcgRIII, and FcgRIV receptors (24).”
- Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. (2006, background): “Interestingly, the isotypes profoundly affected by the absence of TLR9 are the immunoglobulin isotypes frequently associated with inflammation and autoimmunity ( Nimmerjahn and Ravetch, 2005 ).”
- IgEb immune complexes activate macrophages through FcγRIV binding (2007, background): “The relative affinities of FcRs for the different immunoglobulin isotypes are important variables for the 'fine-tuning' of humoral response”
- Fcγ receptors as regulators of immune responses (2008, background): “Similarly, despite the capacity of certain IgG subclasses to bind to several low-affinity receptors in vitro , it has become clear that this does not necessarily imply that all of these receptors are involved in mediating the effector functions of a specific IgG subclass in vivo”