Replica exchange with solute tempering: a method for sampling biological systems in explicit water.

By Pu Liu, Byungchan Kim, Richard A. Friesner, B. Berne. Proceedings of the National Academy of Sciences of the United States of America, 2005

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Bridging Molecular Docking to Molecular Dynamics in Exploring Ligand-Protein Recognition Process: An Overview (2018, background): “…such as the Hamiltonian Replica Exchange (H-REMD), where Hamiltonians are exchanged among replicas instead of temperatures (Fukunishi et al., 2002), and Replica Exchange with Solute Tempering, where a diﬀerent treatment of the central group and the solvent buﬀer is performed (Liu et al., 2005).”
Enhanced Sampling Methods for Molecular Dynamics Simulations [Article v1.0] (2022, background): “For example, in the Replica Exchange Solute Tempering [287] (REST) and REST2 [288] variants, the “temperature" is adjusted for only a part of the system.”
Enhanced Sampling in Molecular Dynamics Using Metadynamics, Replica-Exchange, and Temperature-Acceleration (2013, background): “Among these, a notable idea is that of solute tempering [208,217] which is used for the simulation of solvated biomolecules.”