Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat.

By L. Gray, J. Ostby, John R. Furr, M. Price, D. Veeramachaneni, L. Parks. Toxicological Sciences, 2000

1,114 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/137840154c2e8be31ea42ff7884830fd06af81e3

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In Health, Toxicology and Mutagenesis

1. F. V. vom Saal
2. M. Wittassek
3. H. Koch
4. J. Angerer
5. S. Holgate
6. Thomas Brüning
7. S. Swan

In Molecular Biology

1. Carlos Guerrero-Bosagna
2. M. Manikkam
3. Michael K. Skinner
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Citations in the corpus

• The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. (2000, background): “The effect of DEHP on Leydig cell T production appears to be transient and may be unique to the fetal LC, because T levels are not consistently reduced when these offspring reach maturity (Gray et al., 2000).”
• Endocrine-disrupting chemicals: an Endocrine Society scientific statement. (2009, background): “In the rodent, however, aTDS-like conditioncan be observed after fetal exposure to phthalates (20), and the reduced anogenital distance observed in the rat (22) was observedinarecentepidemiological studyonhumanmalenewborns (23).”
• DNA Methylation of Estrogen Receptor α Gene by Phthalates (2005, background): “Affected individuals display reduced anogenital distances (AGD), retained nipples, cleft phallus with hypospadias, undescended testes, a vaginal pouch, epididymal agenesis, and small or absent sex accessory glands as adults (Gray et al., 2001).”
• Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019 (2019, background): “Numbers of dams with live pups at weaning 19 11 16 14 3 4 8 [31]”
• Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations (2013, background): “male reproductive tract abnormalities consistent with androgen dependent development and impaired testicular function [68,69,70,71,72,73].”
• Assessing exposure to phthalates - the human biomonitoring approach. (2011, background): “However, also for DiNP detrimental reproductive effects have been observed in rats [27, 31], but no-observed-adverse-effect-level (NOAEL) has been determined for these effects so far.”
• Components of plastic: experimental studies in animals and relevance for human health (2009, background): “Di-(2- ethylhexyl) phthalate (DEHP) is the most commonly used phthalate plasticizer for PVC (Matsumoto et al. 2002), but other compounds such as di-butyl phthalate (DBP), used as a fixative in cosmetics and other formulations , are also a cause of concern.”