The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat.
By L. Parks, J. Ostby, Christy R. Lambright, B. Abbott, G. Klinefelter, N. Barlow, L. Gray. Toxicological Sciences, 2000
786 citations recorded by the source corpus.
Subfields: Health, Toxicology and Mutagenesis, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/fca45acffa3e17fac58496760db8cee5722b1b44
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In Health, Toxicology and Mutagenesis
- A. Calafat
- F. V. vom Saal
- Richard S. Judson
- M. Wittassek
- H. Koch
- J. Angerer
- Thomas Brüning
- J. Rochester
In Molecular Biology
Citations in the corpus
- Mechanisms of phthalate ester toxicity in the female reproductive system. (2002, background): “Like DEHP, DBP is also a testicular toxicant and causes reproductive tract malformations in male rats after in utero exposure (Arcadi et al. 1998; Gray et al. 1999; Moore et al. 2001; Mylchreest et al. 1998, 1999; Parks et al. 2000).”
- Assessing exposure to phthalates - the human biomonitoring approach. (2011, background): “DnBP, DiBP, BBzP, DEHP and DiNP have already been proven to cause harmful effects on the developing male reproductive system through, at least in part, a common mode of action by the reduction of testosterone synthesis [21–26, 29–31, 35, 59, 196, 197].”
- Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes (2015, positive): “Environmental Health Perspectives • volume 124 | number 7 | July 2016 1051 cords, and significant reductions in testosterone levels in the fetal rat testis (Parks et al. 2000).”
- Endocrine-disrupting chemicals: an Endocrine Society scientific statement. (2009, background): “DES Fetal rats: hypospadias, cryptorchidism, micropenis, increased transmitted susceptibility to malignancies (28) Hypospadias, cryptorchidism, micropenis, epididymal cysts (28) Increased ER expression in epididymis (43) Reduced insulin-like factor 3 (465) DDT Adult rats: decreased fertility (466) C”
- Components of plastic: experimental studies in animals and relevance for human health (2009, background): “…which act by binding to the androgen receptor and thus inhibit its ability to respond to androgens, phthalates disrupt the development of androgen-dependent structures mainly by inhibiting foetal testicular testosterone biosynthesis (Parks et al. 2000; Wilson et al. 2004; Howdeshell et al. 2008).”
- Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. (2003, background): “Because of the ubiquity of the parent phthalate diesters, human studies using these as biomarkers have involved highly exposed populations (Ching et al. 1981; Dirven et al. 1993; Faouzi et al. 1999; Mettang et al. 1996; Pollack et al. 1985).”