Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure.

By Joseph V. Bonventre. Journal of the American Society of Nephrology, 2003

607 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Update on mechanisms of ischemic acute kidney injury. (2006, background): “Morphologically, repair is heralded by the appearance of dedifferentiated epithelial cells that express vimentin, a marker for multipotent mesenchymal cells (101).”
Biomarkers of acute kidney injury. (2008, background): “When the kidney recovers from acute injury it relies on a sequence of events, including epithelial cell spreading and migration to cover the exposed areas of the basement membrane, cell de-differentiation and proliferation to restore cell number, followed by differentiation, which results in restora”
Recent advances in the pathophysiology of ischemic acute renal failure. (2003, background): “A much more extensive review of the features of dedifferentiation and proliferation of surviving epithelial cells in acute renal failure has recently been written (138).”
Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. (2012, background): “These mechanisms are critical for appropriate repair and regeneration.(70) Cell cycle abnormalities affect the outcome of AKI.”
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury (2010, positive): “The potent capacity of tubular epithelial cells to proliferate and replace lost cells is crucial for repair and enables recovery from many ischemic or toxic insult”