Molecular understanding and modern application of traditional medicines: triumphs and trials.

By T. Corson, C. Crews. Cell, 2007

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How researchers see this paper

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Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment (2019, background): “The ﬁve ﬂavors of some TCMs were predicted by these established models, providing crucial support for research on TCM compatibility.”
Discovery and resupply of pharmacologically active plant-derived natural products: A review (2015, background): “Particularly in the context of drug discovery from medicinal plants, a big advantage is that sometimeswell documented ethnopharmacological information about the traditional use is available,which canprovide hints for compounds therapeutically effective in humans (Corson and Crews, 2007; Heinrich, 20”
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, neutral): “Celastrol is an inducer of NQO1 (Albena T. Dinkova-Kostova and Paul Ta-lalay, unpublished observations) and a potent inhibitor of NF k B (136, 400).”
Treatment of Obesity with Celastrol (2015, positive): “Celastrol reportedly has anti-cancer effects both in vitro and in vivo (Corson and Crews, 2007).”
Natural products and drug discovery (2009, background): “Pharmacists and chemists are therefore turning their attention back to nature’s toolbox: indeed, some promising drug candidates such as huperzine A, triptolide, celastrol, capsaicin and curcumin, have come from this recent focus on natural agents ( Ji & Zhang, 2008; Corson & Crews, 2007).”