Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
By Nicholas T. Ingolia, Sina Ghaemmaghami, J. R. Newman, Jonathan S. Weissman. Science, 2009
3,664 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4edda6ee599caa3e991548a17b92f2632efc0ad0
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Steven L. Salzberg
- Chuan He
- David P. Bartel
- Jonathan S. Weissman
- Mark Borodovsky
- Alexandre Lomsadze
- Cole Trapnell
- Nicholas T. Ingolia
Citations in the corpus
- Codon optimality is a major determinant of mRNA stability (2015, background): “Several ribosomal profiling studies have failed to detect codon-specific differences in the translation of optimal and non-optimal codons (Ingolia et al., 2009; Qian et al., 2012; Charneski and Hurst, 2013).”
- Understanding the contribution of synonymous mutations to human disease (2011, result): “This view is consistent with a genome-wide analysis of translation based on deep sequencing of ribosome-protected mRNA fragment”
- The scanning mechanism of eukaryotic translation initiation. (2014, positive): “The relative importance of the different helicases in scanning versus 43S attachment should be defined by use of genome-wide approaches, such as ribosome profiling (248), so as to identify the importance of each factor for the translation of any given mRNA.”
- Codon Bias as a Means to Fine-Tune Gene Expression (2015, positive): “Ribosome density profiling now allows genome-wide analysis of ribosome distribution down to a single-codon resolution (Figure 3) (Ingolia, 2014; Ingolia et al., 2009).”
- Ribosome profiling provides evidence that large non-coding RNAs do not encode proteins (2013, methodology): “This method involves digestion of RNA followed by separation of 80S ribosomes based on their size and density through a sucrose cushion (Ingolia et al., 2009, 2011).”
- RNA sequencing: advances, challenges and opportunities (2010, background): “These strategies have already begun to contribute to our understanding of transcriptomes, including mapping of translation states of RNAs (for example, polysome profiling”