Neurotechnique A Chemical-Genetic Approach to Studying Neurotrophin Signaling

By X. Chen, Haihong Ye, R. Kuruvilla, N. Ramanan, K. Scangos, Chao Zhang, N. Johnson, Pamela M England, Kevan M. Shokat, D. Ginty. 2005

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A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. (2006, unknown): “This approach has been successful both in cultured cells and in mice (Bishop et al., 2000; Wang et al., 2003, Chen et al., 2005); however, it is limited to ATPases and GTPases.”
DREADDs for Neuroscientists (2016, methodology): “Over the past two decades, a large number of chemogenetic (also known as “chemical genetic”; (Bishop et al., 1998; Strader et al., 1991; Chen et al., 2005; Sternson and Roth, 2014) platforms have been invented that have been useful for biologists in general and most especially for neuroscientists.”
Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning (2010, unknown): “In TrkBF616A knockin mice, the endogenous TrkB gene is replaced by TrkBF616A, so that TrkB kinase activity can be selectively inhibited by the membrane-permeable small molecule 1NMPP1 (Chen et al., 2005).”
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone (2010, background): “TrkB F616A knockin mice, when treated with 1NMPP1, exhibit an effective TrkB-null phenotype (15).”