Regulation of HSF1 function in the heat stress response: implications in aging and disease.

By J. Anckar, Lea Sistonen. Annual Review of Biochemistry, 2011

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HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. (2012, neutral): “For instance, impaired protein homeostasis driven by the accumulation of mutant, misfolding-prone oncoproteins, aneuploidy, and the increased rate of translation in cancer could chronically stimulate HSF1 activation by releasing it from sequestration from chaperones (Anckar and Sistonen, 2011).”
Glutathione: new roles in redox signaling for an old antioxidant (2014, background): “, 2001), heat shock factor 1 (HSF1; Jacquier-Sarlin and Polla, 1996; Anckar and Sistonen, 2011), and NE2FL2 (Itoh et al.”
Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, background): “The regulatory domain in HSF1 negatively regulates the transactivation domain and is targeted by several PTMs including phosphorylation, sumoylation and acetylation [147].”