Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

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Type 2 diabetes as an inflammatory disease (2011, background): “Initial studies are beginning to characterize the macrophage subtypes in the adipose tissue under different conditions, including in lean or obese animals and individual”
Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes (2008, methodology): “Mice were injected with PKH26 that label ATMs with near 100% efficiency (17).”
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes (2020, background): “In obesity, macrophages surround dead adipocytes (i.e., forming crown-like structures) and secrete an array of pro-inflammatory cytokines that lead to local and systemic inflammation and IR (Lumeng et al., 2007a; Haase et al., 2014).”
Adipose tissue plasticity in health and disease (2022, background): “In support of this idea, lipidstoring macrophages, resembling foam cells, accumulate in obese adipose tissue (Lumeng et al., 2007b).”