Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro

By S. Bryant, C. Nuttelman, K. Anseth. Journal of Biomaterials Science. Polymer Edition, 2000

723 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Organic Chemistry, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/4e2e2c0e68a8958bab2fe78e53449649922327c7

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In Biomedical Engineering

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In Pulmonary and Respiratory Medicine

Citations in the corpus

PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine (2008, neutral): “tion, as they are highly biocompatible to the cells under proper polymerization conditions (9).”
The use of renewable feedstock in UV-curable materials - A new age for polymers and green chemistry (2013, neutral): “[102]”
Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair (2016, background): “Moreover, the long-term effects of Irgacure 2959, albeit relatively cell friendly compared with other UV photoinitiators [32], have not yet been studied fully.”
The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability. (2014, positive): “From all PIs used for the photo-initiated free-radical polymerization of cell-laden hydrogels, I2959 is most commonly applied for several reasons [22,33,34]: (i) it is slightly water soluble, enabling applications in aqueous environments, (ii) in the absence of UV-A irradiation, no significant cytot”
Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffolds. (2003, result): “Our findings were similar to those involving the cytotoxicity effects of Irgacure 2959 (also called Darocur 2959) on fibroblasts (Bryant et al., 2000).”
Hydrogel scaffolds for tissue engineering: Progress and challenges (2013, background): “For instance, the development of photo-crosslinkable matrices that utilize blue light for crosslinking has further advanced and enhanced the safety of this technology for tissue engineering purposes.(49) Also, in a similar photolithography technique known as laser scanning lithography, a laser light”
Engineering cartilage tissue. (2008, background): “Careful screening of photoinitiating conditions has been performed to optimize cell viability within these crosslinked networks [116].”
A review on stereolithography and its applications in biomedical engineering. (2010, background): “hydroxy‐1‐[4‐(2‐hydroxyethoxy)phenyl]‐2‐methyl‐1‐propanone) [62], is cytotoxic at the concentrations necessary: cell survival is approximately 25 % after 24 h in an aqueous PEG‐DMA resin containing 0.”
Review: Photopolymerizable and Degradable Biomaterials for Tissue Engineering Applications (2007, positive): “To address toxicity during polymerization, several groups have investigated initiation conditions that lead to viable cells upon polymerization.(19,20) One specific initiating system that uses the water-soluble photoinitiator Irgacure 2959 (I2959, 2-hydroxy-1-[4-(hydroxyethoxy) phenyl]-2-methyl1-pro”
In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, positive): “Even so, several other reports have demonstrated that at low photoinitiator concentrations, photocrosslinking allows for encapsulation of many different cell types with minimal cytotoxicity [98,99], but may result in altered gene expression due to the high prevalence of free radicals [100] implying ”