Macrophages Facilitate Electrical Conduction in the Heart
By M. Hulsmans, S. Clauss, Ling Xiao, A. Aguirre, K. King, A. Hanley, W. Hucker, E. M. Wülfers, G. Seemann, G. Courties and 24 more. Cell, 2017
886 citations recorded by the source corpus.
SUMMARY Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophages expressing connexin 43. When coupled to spontaneously beating cardiomyocytes via connexin 43-containing gap junctions, cardiac macrophages have a negative resting membrane potential and depolarize in synchrony with cardiomyocytes. Conversely, macrophages render the resting membrane potential of cardiomyocytes more positive and, according to computational modeling, accelerate their repolarization. Photostimulation of channelrhodopsin 2-expressing macrophages improves atrioventricular conduction, while conditional deletion of connexin 43 in macrophages and congenital lack of macrophages delay atrioventricular conduction. In the Cd11bDTR mouse, macrophage ablation induces progressive atrioventricular block. These observations implicate macrophages in normal and aberrant cardiac conduction.
Subfields: Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/fa761af0335bf480846446891ae618644142f709
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Citations in the corpus
- Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches (2019, methodology): “We first compared lung IM transcriptomes generated by scRNA-seq with published transcriptomes of ATMs (21) and AVMs (22). cMAP analysis revealed that lung Lyve1loMHCIIhi and Lyve1hiMHCIIlo IMs aligned closely with the gene expression patterns of CX3CR1− and CX3CR1+ brown ATMs, respectively (Fig.”
- Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction (2018, positive): “This is in contrast to resident CCR2 − macrophages, which are primarily of embryonic origin and promote angiogenesis and cardiomyocyte proliferation, similar to neonatal macrophages 8, 9, 16 .”
- The role of macrophages in the resolution of inflammation. (2019, background): “Resident CCR2-negative macrophages promote coronary development and cardiac regeneration and facilitate electrical conduction within the atrioventricular node (91, 92).”