CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

By Tomohisa Kato, M. Delhase, Alexander Hoffmann, M. Karin. 2003

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Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway (2006, background): “For example, a CK2 (casein kinase II)-dependent pathway has been described that is activated in response to short wavelength ultraviolet (UV-C) light treatment or expression of the Her2/Neu oncogene (Romieu-Mourez et al., 2002; Kato et al., 2003).”
Good cop, bad cop: the different faces of NF-κB (2006, background): “casein kinase II (CK2)-dependent phosphorylation and degradation of IkBa that occurs in response either to shortwavelength ultraviolet (UV-C) light or expression of the Her2/ Neu oncogene.(18,19) In these circumstances, IkBa phosphorylation occurs at C-terminal sites, and not at serines 32/36.”
An Extensive Survey of CK2 α and β Subunits in Arabidopsis: Multiple Isoforms Exhibit Differential Subcellular Localization (2006, background): “In fact, besides the classical function of rRNA synthesis, the nucleolus has also been associated with the cellular response to stress and apoptosis (Pendle et al. 2005), processes where CK2 participation has also been demonstrated (Gerber et al. 2000, Kato et al. 2003, Yamane and Kinsella 2005).”
Inflammation, a Key Event in Cancer Development (2006, background): “InB degradation may be also through the phosphorylation by casein kinase 2 (122, 123).”