BH3 - only proteins: evolutionarily conserved proapoptotic Bcl - 2 family members essential for init

By P. Bouillet, A. Strasser. 2002

390 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4547b669cb2b8ae9500266f590c493b648f7b79a

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Citations in the corpus

Anoikis: an emerging hallmark in health and diseases (2012, background): “ANGPTL4, angiopoietin-like 4 protein; Bad, Bcl2associated agonist of cell death; Bak, Bcl2-antagonist/ killer; Bax, Bcl2-associated X protein; Bcl2, B cell leukaemia/lymphoma 2; Bok, Bcl2-related ovarian killer; Bid, BH3 interacting domain death agonist; Bik, Bcl2-interacting killer; Bmf, Bcl2 modif”
Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization (2004, background): “Translocation is initiated by a variety of mechanisms, which include transcriptional regulation, posttranslational modification and/or conformational change [2,48,49].”
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (2006, background): “The activity of BH3-only proteins is kept in check by several mechanisms, keeping these proteins away from the multidomain Bcl-2 counterparts under normal circumstances, yet allowing their rapid activation under stress conditions (Bouillet and Strasser, 2002).”
Life in the balance: how BH3-only proteins induce apoptosis. (2005, background): “As reviewed previously [1 ,2 ,6–8,9 ,10], the BH3-only proteins participate in vital biological processes, and their absence contributes to autoimmunity and neoplasia.”
Apoptosis - the p53 network (2003, background): “…prosurvival proteins, whose members are most structurally similar to Bcl-2, such as Bcl-XL; pro-apoptotic proteins, Bax and Bak, which are structurally similar to Bcl-2 and Bcl-XL and antagonize their pro-survival functions; and the pro-apoptotic ‘BH3-only’ proteins (Bouillet and Strasser, 2002).”
`The stress of dying': the role of heat shock proteins in the regulation of apoptosis (2004, background): “A subset of the pro-apoptotic members, including Bim, Bid and Bad, contain only the Bcl-2-homology 3 (BH3) domain, which mediates homo/heterodimeric association of various family members (Bouillet and Strasser, 2002).”
Ways of dying: multiple pathways to apoptosis. (2003, background): “The BH3-only proteins trigger apoptosis in response to developmental cues, insufficient trophic support, and intracellular damage (Huang and Strasser 2000; Bouillet and Strasser 2002; Puthalakath and Strasser 2002).”