Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond

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Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-oxide in Patients with Heart Failure: Refining the Gut Hypothesis (2014, positive): “receiver-operating characteristic curve (AUC) were calculated according to mortality risk estimated using Cox models adjusted for the above-mentioned traditional risk factors with versus without TMAO, as previously described (14,15).”
A predictive model for progression of chronic kidney disease to kidney failure. (2011, neutral): “Reclassification improvementwasquantifiedusing the net reclassification improvement (NRI) statistic.(21) Sensitivity Analysis.”
Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease (2014, methodology): “Net reclassification and area under receiver operator characteristic curve were calculated according to mortality risk estimated using Cox models adjusted for above-mentioned traditional risk factors with versus without TMAO as previously described.(22) All analyses performed used R 2.”