Faculty Opinions recommendation of A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

By I. Ambudkar, H. L. Ong. 2011

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Mitochondria: In Sickness and in Health (2012, background): “…adenosine monophosphate; ATP, adenosine triphosphate; Ac, acetyl group. participate in Ca2+ homeostasis, shaping the spatiotemporal distribution of this second messenger by buffering Ca2+ flux from the plasma membrane and endoplasmic reticulum (ER) (Baughman et al., 2011; De Stefani et al., 2011).”
Engineered ascorbate peroxidase as a genetically-encoded reporter for electron microscopy (2012, background): “(4) Vimentin intermediate filaments in a COS-7 cell.”
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. (2014, background): “166, 434) with recent molecular identification of the Ca(2) -uniporter (36, 105) and Ca(2) /2Na exchanger (332), the role of Ca(2) in ROS production in mitochondria remains controversial.”
Neuronal calcium signaling: function and dysfunction (2014, background): “MCU mediates the entry of Ca2+ into the mitochondrial matrix [80, 81] which is driven by the negative membrane potential generated by the activity of the respiratory chain components of the inner membrane.”
Initiation and perpetuation of NLRP3 inflammasome activation and assembly (2015, background): “The mitochondrial calcium uniporter (MCU) is important for mitochondrial Ca uptake, which buffers elevations in cytosolic Ca, but excessive uptake leads to mitochondrial dysfunction (79, 83, 84).”