The gut microbiota as an environmental factor that regulates fat storage.

By F. Bäckhed, Hao Ding, Ting Wang, L. Hooper, G. Koh, A. Nagy, C. Semenkovich, Jeffrey I. Gordon. Proceedings of the National Academy of Sciences of the United States of America, 2004

6,053 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/4cab880a62df06a300814ace9fb542643dac1863

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Citations in the corpus

Next-generation DNA sequencing methods. (2008, background): “Epigenomics: seeks to define the influence of changes to gene expression that are independent of gene sequence studied is the lower intestine of humans, first characterized by 16S rRNA classification (4, 5, 28) and more recently by 454 pyrosequencing in adult humans (16, 36, 48) and in infants (25, ”
The Role of Microbial Amino Acid Metabolism in Host Metabolism (2015, background): “can significantly modulate host hepatic and systemic lipid metabolism [9], energy balance [17], and glycemic control [18], which may reduce diet-induced obesity, insulin resistance, and T2DM.”
Histopathology of pediatric nonalcoholic fatty liver disease (2005, background): “Most subjects had mildly abnormal serum aminotransferase activity, although values ranged from normal to markedly elevated; median and ranges were alanine aminotransferase (ALT) 79 (16-664), aspartate aminotransferase 53 (22-273), and -glutamyltransferase 47 (9194).”
Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances (2016, background): “…changes in the gut microbiota, reduced bacterial diversity, and altered representation of bacterial genes and metabolic pathways, differences that endow the obesity−associated microbiota with an increased capacity to harvest energy from the diet (Backhed et al., 2004; Turnbaugh et al., 2006, 2009).”
INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE (2012, neutral): “In addition to the potential roles of SFAs as endogenous activators of Tlr signaling, low levels of endotoxin derived from bowel flora are present in the portal circulation, with levels varying dependent on various factors, including diet (Amar et al., 2008; Bäckhed et al., 2004).”
Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors (2010, background): “In many ways, the gut microbiota does behave as an environmental factor implicated in fat storage (14)or immune systemdevelopment (44–46).”
High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway (2012, background): “Moreover, conventionalization of adult GF mice with a normal microbiota harvested from conventionally raised animals (CONV) produced an increase in body fat [14].”