Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors

By A. Benson, S. A. Kelly, Ryan M Legge, Fangrui Ma, Soo Jen Low, Jaehyoung Kim, Min Zhang, Phaik Lyn Oh, D. Nehrenberg, K. Hua and 5 more. Proceedings of the National Academy of Sciences of the United States of America, 2010

1,265 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5db4fcc71b304e6459e5b7608667fc5524ec9252

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

In Molecular Biology

Citations in the corpus

Genetic determinants of the gut microbiome in UK Twins (2016, positive): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript from an advanced intercross line (Benson et al., 2010).”
Conducting a Microbiome Study (2014, background): “In large studies with multiple litter/cage replicates, the variance in the data that is attributable to the maternal effect can be accounted for in statistical models (Benson et al., 2010).”
Bacterial communities in meerkat anal scent secretions vary with host sex, age, and group membership (2014, neutral): “the major histocompatibility complex (Lanyon et al. 2007; Zomer et al. 2009; Benson et al. 2010).”
How informative is the mouse for human gut microbiota research? (2015, background): “…founder effects A wide range of experiments in which gene-knockout mouse models have been created, yielding different genetic backgrounds, have highlighted that genetics is an important determinant of gut microbiota composition (Benson et al., 2010; Hildebrand et al., 2013; Kovacs et al., 2011).”
Diet dominates host genotype in shaping the murine gut microbiota (2014, background): “Associations between genetic loci and the abundance of bacterial taxa have been described in mice fed a controlled diet (Benson et al., 2010; McKnite et al., 2012) and in humans (Li et al.”
Beyond the Venn diagram: the hunt for a core microbiome. (2012, background): “Collectively, these studies provide preliminary evidence of cores, and the resulting enthusiasm has produced almost as many reviews, commentary and opinion articles as primary research (e.g. Tschop et al., 2009; Turnbaugh and Gordon, 2009; Vael and Desager, 2009; Bäckhed, 2010; Benson et al., 2010; ”
Integrative omics for health and disease (2018, background): “Recently, human genetic profiles have been shown to influence overall gut microbiota composition 116,117 , which could suggest putative causal explanations for some disease-associated genetic loci 118 (for recent reviews, see REFS 119,120 ).”