Adaptive recognition by nucleic acid aptamers.

By T. Hermann, Dinshaw J. Patel. Science, 2000

1,537 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4c98975d2200bd3d5acfe916a486a794bec20edf

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In Molecular Biology

Citations in the corpus

SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands. (2007, background): “Binding of the aptamer to the target results from structure compatibility, stacking of aromatic rings, electrostatic and van der Waals interactions, and hydrogen bondings, or from a combination of these effects (Hermann and Patel, 2000).”
Circular Dichroism Techniques: Biomolecular and Nanostructural Analyses‐ A Review (2009, background): “This effect can be attributed to the possibility of stable hydrogen bonding between the guanine moiety of arginine and interior DNA bases (94,99).”
Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria. (2003, background): “Allosteric remolecules (Gold et al., 1995; Hermann and Patel, 2000).arrangement of mRNA structure is mediated by ligand Furthermore, RNAs exhibit sufficient structural com-binding, and this results in modulation of gene expresplexity to permit the formation of allosteric domains thatsion.”
Preparation of aptamer-linked gold nanoparticle purple aggregates for colorimetric sensing of analytes (2006, background): “1 in green) switches its structure and binds two adenosine molecule”
Gene regulation by riboswitches (2004, background): “Second, does RNA even have sufficient structural potential to serve as a highly specific receptor for small organic compounds? Indeed, numerous RNAs or APTAMERS”
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease (2006, background): “They also bind with high affinity, displaying dissociation constants in the picomolar to low-nanomolar rang”