Deletion of Cdc42 Enhances ADAM17-Mediated Vascular Endothelial Growth Factor Receptor 2 Shedding and Impairs Vascular Endothelial Cell Survival and Vasculogenesis

By Yixin Jin, Yang Liu, Qiong-Qiong Lin, Jieli Li, J. Druso, M. Antonyak, C. Meininger, Shenyuan L. Zhang, D. Dostal, J. Guan and 2 more. 2013

52 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology

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In Immunology and Allergy

1. S. Zhong
2. R. Khalil

In Molecular Biology

1. S. Zhong
2. R. Khalil

Citations in the corpus

• A Disintegrin and Metalloproteinase (ADAM) and ADAM with Thrombospondin Motifs (ADAMTS) Family in Vascular Biology and Disease (2019, background): “Also, deletion of Cdc42 increases the activity of ADAM-17 and enhances VEGFR-2 shedding and reduces vascular endothelial cell survival and angiogenesis, and inhibition of ADAM-17 can partially reverse Cdc42 deletion-induced EC apoptosis [137].”