Blood–brain barrier dysfunction in parkinsonian midbrain in vivo

By R. Kortekaas, K. Leenders, J. V. van Oostrom, W. Vaalburg, J. Bart, A. Willemsen, N. Hendrikse. Annals of Neurology, 2005

716 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/4c416834d25a513fac9ef774dcf6db7c0de5a872

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Tansey
2. M. Goldberg
3. Heidrun Potschka
4. P. Whitton
5. N. Abbott
6. Wolfgang Löscher
7. P. Jenner
8. S. Duty

In Neurology

1. Wolfgang Löscher
2. Heidrun Potschka
3. M. Tansey
4. M. Goldberg
5. P. Whitton
6. Cynthia Hajal
7. N. Abbott
8. Siti R. Yusof

Citations in the corpus

• The blood-brain barrier in health and chronic neurodegenerative disorders. (2008, neutral): “The involvement of the BBB P-gp transporter in PD pathogenesis has been demonstrated by verapamil (a P-gp substrate) retention on PET scans of the midbrain, but not of other brain regions, in PD individuals (Kortekaas et al., 2005).”
• Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions (2006, background): “Decrease of functional activity of P-gp was demonstrated in human brain tissue in Parkinson’s disease (Kortekaas et al. 2005).”
• Neuroinflammation in Parkinson’s disease and its potential as therapeutic target (2015, background): “tive diseases including PD [90, 91].”
• Structure and function of the blood-brain barrier. (2010, background): “Kortekaas et al., 2005 Desai et al., 2007 Bartels et al., 2008 Epilepsy Transient BBB opening in epileptogenic foci, and upregulated expression of P-glycoprotein and other drug efflux transporters in astrocytes and endothelium.”
• 3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “Loss of BBB integrity is associated with Alzheimer's disease [4,5], Parkinson's disease [6], and multiple sclerosis [7], as well as with brain cancer [8].”
• Drug resistance in brain diseases and the role of drug efflux transporters (2005, background): “In addition, it has been proposed that the expression pattern of Pgp has a key role in the aetiology and pathogenesis of brain diseases such as Alzheimer's disease, Parkinson's disease and brain HIV infectio”
• Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention (2009, background): “Given that reduced function of efflux pumps that regulate BBB permeability has been reported for PD patients (Kortekaas et al., 2005), it is highly likely that the neuroinflammatory activity in the”
• Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. (2008, background): “Since a previous report indicated that the blood-brain barrier (BBB) may be dysfunctional in PD patients (11), we examined whether MPTP-associated BBB disruption could account for a passive entry of lymphocytes into the brain.”