SREBP transcription factors: master regulators of lipid homeostasis.
By D. Eberlé, B. Hegarty, P. Bossard, P. Ferré, F. Foufelle. Biochimie, 2004
1,531 citations recorded by the source corpus.
Subfields: Biochemistry, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/4bfe125e82d74fb5027718c76c42d8f676fa2d5c
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In Biochemistry
In Molecular Biology
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- A. Schulze
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In Surgery
Citations in the corpus
- Gene networks driving bovine milk fat synthesis during the lactation cycle (2008, background): “An additional function of SREBP2 is to induce mRNA expression of genes involved in FA synthesis [85].”
- Triglyceride metabolism in the liver (2017, neutral): “It is induced after fasting/refeeding and in response to insulin, and downregulated via the cAMP-dependent signaling pathway during nutrient deprivation (76, 186, 230).”
- Cancer Cell Metabolism: One Hallmark, Many Faces (2012, background): “the expression of several genes involved in fatty acid and sterol biosynthesis in response to growth factors or intracellular sterol levels (58).”
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth (2008, background): “The family of sterol regulatory element binding proteins (SREBP) consists of three closely related members: SREBP1a, SREBP1c, and SREBP2 (Eberle et al., 2004).”
- Liver lipid metabolism. (2008, background): “Overexpression of hepatic SREBP-1c causes only a selective induction of lipogenic genes, with no effect on cholesterol synthesis genes (Eberle et al., 2004).”
- Transcriptional control of adipose lipid handling by IRF4 (2011, positive): “During feeding, insulin exerts its prolipogenic functions via a transcription factor called sterol regulatory element binding protein 1c (SREBP1c), while the effects of carbohydrates and polyunsaturated fatty acids are mediated by carbohydrate response element binding protein (ChREBP) and liver X re”
- The role of FoxO in the regulation of metabolism (2008, background): “SREBP-1c is a global regulator of lipogenic gene transcription (Eberle et al., 2004).”